860659P

sphingosine-1-phosphate-d7

Avanti Research^™ - A Croda Brand

• Synonym(e): D-erythro-sphingosine-d7-1-phosphate
• Empirische Formel (Hill-System): C₁₈H₃₁D₇NO₅P
• CAS-Nummer: 2260670-15-1
• Molekulargewicht: 386.51
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 1 mg (860659P-1mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [H][C@@]([C@]([NH3+])([H])COP([O-])(O)=O)(O)/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
• InChI: 1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1/i1D3,2D2,3D2
• InChIKey: DUYSYHSSBDVJSM-AVMMVCTPSA-N

Beschreibung

Allgemeine Beschreibung

Sphingosine-1-phosphate (S1P) or D-erythro-sphingosine-d7-1-phosphate, is a deuterated sphingolipid. S1P, a zwitterionic sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in insects, yeasts and plants. S1P is synthesized from the sphingosine kinase (Sph) 1 and SphK2 present in cytosol and nucleus, respectively.[1]

Anwendung

Sphingosine-1-phosphate (S1P)-d7 has been used as a standard in ultra-high performance liquid chromatography (UHPLC)-Q exactive for validation and quantitative analyses of S1P.[1][2]

Biochem./physiol. Wirkung

Sphingosine-1-phosphate (S1P) plays a vital role in mammalian brain and cardiac development. It is essential for maturation of the systemic circulatory system and lymph vessels. Additionally, S1P is implicated in trafficking and effector functions of lymphocytes and other blood stem cells. It also provides protection against various forms of tissue injury. S1P also acts as a tumor promoting lipid.[3] S1P has an ability to enhance erythrocyte glycolysis and oxygen delivery therefore, it can be used to treat tissue hypoxia.[1]

Verpackung

5 mL Amber Glass Screw Cap Vial (860659P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available