791056P
Avanti
2-OHOA
2-hydroxyoleic acid (sodium salt), powder
Synonym(e):
Minerval; NaCHOleate; 2OHOA
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1 G
216,00 €
About This Item
Empirische Formel (Hill-System):
C18H33NaO3
CAS-Nummer:
Molekulargewicht:
320.44
MDL-Nummer:
UNSPSC-Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
Form
powder
Verpackung
pkg of 1 × 1 g (791056P-1g)
Hersteller/Markenname
Avanti Research™ - A Croda Brand 791056P
Lipid-Typ
neutral lipids
neutral glycerides
Versandbedingung
dry ice
Lagertemp.
−20°C
Allgemeine Beschreibung
Anwendung
2-hydroxyoleic acid (2-OHOA) is suitable for use:
- to study its antihypertensive action in adult spontaneously hypertensive rats (SHRs)[1]
- to study the chemical structure-effect relation of 2-OHOA in the reduction of body weight in rats[2]
- as an antitumor compound, to study its effect on xenografts lipidome based on imaging mass spectrometry (IMS)[3]
Biochem./physiol. Wirkung
2-Hydroxy Oleic Acid is an inducer of cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2-Hydroxy Oleic Acid increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.
Verpackung
20 mL Clear Glass Screw Cap Vial (791056P-1g)
Rechtliche Hinweise
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Lagerklassenschlüssel
11 - Combustible Solids
Hier finden Sie alle aktuellen Versionen:
Analysenzertifikate (COA)
Lot/Batch Number
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats
Vogler O, et al.
International Journal of Obesity, 32(3), 464-464 (2008)
Alena Khmelinskaia et al.
Langmuir : the ACS journal of surfaces and colloids, 30(8), 2117-2128 (2014-02-05)
Recent research regarding 2-hydroxylated fatty acids (2OHFAs) showed clear evidence of their benefits in the treatment of cancer, inflammation, and neurodegenerative disorders such as Alzheimer's disease. Monolayer compressibility isotherms and isothermal titration calorimetry of 2OHFA (C18-C22) in phosphatidylcholine/phosphatidylethanolamine/sphingomyelin/cholesterol (1:1:1:1 mole
Victoria Llado et al.
Journal of cellular and molecular medicine, 14(3), 659-670 (2009-05-06)
Minerval is an oleic acid synthetic analogue that impairs lung cancer (A549) cell proliferation upon modulation of the plasma membrane lipid structure and subsequent regulation of protein kinase C localization and activity. However, this mechanism does not fully explain the
Silvia Terés et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(22), 8489-8494 (2012-05-16)
Despite recent advances in the development of new cancer therapies, the treatment options for glioma remain limited, and the survival rate of patients has changed little over the past three decades. Here, we show that 2-hydroxyoleic acid (2OHOA) induces differentiation
Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase
Alemany R
Journal of Lipid Research, 47(8), 1762-1770 (2006)
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
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