G8503

18α-Glycyrrhetinsäure

≥95%

• Synonym(e): 18α-Glycyrrhetinsäure, 18-Isoglycyrrhetinsäure
• Empirische Formel (Hill-System): C₃₀H₄₆O₄
• CAS-Nummer: 1449-05-4
• Molekulargewicht: 470.68
• EG-Nummer: 215-907-9
• MDL-Nummer: MFCD00064897
• UNSPSC-Code: 12352115
• PubChem Substanz-ID: 57654221
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• SMILES String: [H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)C4[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O
• InChI: 1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1
• InChIKey: MPDGHEJMBKOTSU-PMTKVOBESA-N

Beschreibung

Allgemeine Beschreibung

18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice.[1] It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1).[2] It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).[3]

Anwendung

18α-Glycyrrhetinic acid may be used to synthesize:[4]

• 3-keto-18α-glycyrrhetinic acid
• methyl esters of 18α-glycyrrhetinic acid
• methyl esters of 3-keto-18α-glycyrrhetinic acid

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves