902675

BocNH-PEG₆-acid

• Synonym(e): 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH₂COOH
• Empirische Formel (Hill-System): C₁₉H₃₇NO₁₀
• CAS-Nummer: 391684-36-9
• Molekulargewicht: 439.50
• MDL-Nummer: MFCD30489670
• UNSPSC-Code: 12352106
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Eignung der Reaktion: reagent type: linker
• Brechungsindex: n/D 1.4657
• Funktionelle Gruppe: Boc; amine; carboxylic acid
• Lagertemp.: −20°C
• SMILES String: OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C19H37NO10/c1-19(2,3)30-18(23)20-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17(21)22/h4-16H2,1-3H3,(H,20,23)(H,21,22)
• InChIKey: ZKCDWMFMVAYYED-UHFFFAOYSA-N

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG₆-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Sonstige Hinweise

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol

Ultrasmall particle of iron oxide-RGD peptidomimetic conjugate: synthesis and characterization

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable