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Dokumente

696420

Sigma-Aldrich

(R)-Piperidin-3-carbonsäure-ethylester

97%

Synonym(e):

(R)-ethyl-nipecotat

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About This Item

Empirische Formel (Hill-System):
C8H15NO2
CAS-Nummer:
25137-01-3
Molekulargewicht:
157.21
MDL-Nummer:
MFCD03093637
UNSPSC-Code:
12352100
PubChem Substanz-ID:
329761827
NACRES:
NA.22

Assay

97%

Form

liquid

Dichte

1.092 g/mL at 25 °C

SMILES String

CCOC(=O)[C@@H]1CCCNC1

InChI

1S/C8H15NO2/c1-2-11-8(10)7-4-3-5-9-6-7/h7,9H,2-6H2,1H3/t7-/m1/s1

InChIKey

XIWBSOUNZWSFKU-SSDOTTSWSA-N

Anwendung

Reactant for synthesis of:
  • DPP-4 inhibitors
  • Dual H1/5-HT2A receptor antagonists for treatment of sleep disorders
  • Serotonin and noradrenaline reuptake inhibitors
  • GABA uptake inhibitors

Reactant for stereocontrolled hydoiodination of alkynes

Used for an orally potent anti-anxiety drug

Piktogramme

CorrosionExclamation mark
GHS05,GHS07

Signalwort

Danger

Gefahreneinstufungen

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

219.2 °F

Flammpunkt (°C)

104 °C

Persönliche Schutzausrüstung

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

S H Zorn et al.
The Journal of pharmacology and experimental therapeutics, 242(1), 173-178 (1987-07-01)
Previous reports have suggested that the ethyl ester of (R)-nipecotic acid ethyl ester [(R)-NAEE] displays cholinomimetic properties in vivo. The present study was undertaken to characterize more fully this action by examining the effects of (R)-NAEE in a number of
T Andree et al.
Life sciences, 32(19), 2265-2272 (1983-05-09)
THIP (4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridone-3-ol), a direct acting GABA receptor agonist, has been shown to have antinociceptive properties. To determine whether tolerance develops to the analgesic response, mice received multiple injections of THIP for up to 21 days after which analgesia
M Potegal
Psychopharmacology, 89(4), 444-448 (1986-01-01)
The GABA uptake inhibitor ethyl (R,S)-nipecotate produces a dose-dependent suppression of aggression in highly aggressive hamsters but not in minimally aggressive ones. This suppression occurs at doses below those producing peripheral cholinergic effects; at the highest dose used it persists
Wen-Juan Zhao et al.
Acta pharmacologica Sinica, 24(10), 991-995 (2003-10-09)
The changes of seizure susceptibility of transgenic mice overexpressing GABA transporter-1 (GAT-1) were studied to clarify the possible role of GABAergic transmission in epileptogenesis. Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA) respectively.
A M Rustum et al.
Journal of pharmaceutical and biomedical analysis, 17(8), 1439-1447 (1998-11-04)
Chiral HPLC methods were developed and validated for tiagabine.HCl and its two chiral precursors to determine the chiral purity of the three compounds to ensure the quality of the final product which is used as a new antiepileptic drug. Tiagabine.HCl
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