670359

Acetylthiomethyl-diphenylphosphin-Boran-Komplex

≥98.0%

• Synonym(e): (T-4)-[S-[(Diphenylphosphino-κP)methyl] ethanethioate]trihydroboron
• Empirische Formel (Hill-System): C₁₅H₁₈BOPS
• CAS-Nummer: 446822-71-5
• Molekulargewicht: 288.15
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329760266
• NACRES: NA.22

Eigenschaften

• Assay: ≥98.0%
• Form: solid
• Eignung der Reaktion: reaction type: click chemistry; reagent type: ligand; reaction type: Staudinger Reaction
• mp (Schmelzpunkt): 52-55 °C
• Funktionelle Gruppe: phosphine
• Lagertemp.: 2-8°C
• SMILES String: B.CC(=O)SCP(c1ccccc1)c2ccccc2
• InChI: 1S/C15H15OPS.BH3/c1-13(16)18-12-17(14-8-4-2-5-9-14)15-10-6-3-7-11-15;/h2-11H,12H2,1H3;1H3
• InChIKey: MXPNVFCCEGQGEN-UHFFFAOYSA-N

Beschreibung

Anwendung

• Traceless Staudinger ligation reagent with borane protecting group.
• The borane group stabilizes the phosphine against oxidation and can be easily removed with mild basic or acidic conditions to yield the active phosphine.[1]
• After reaction with an azide, the phosphine is eliminated in the presence of water to yield a native amide bond.[2]
• Used in the synthesis of cyclic peptides.[2]

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Rechtliche Hinweise

Sold under license for research and development purposes only. US Patent 6,974,884 and related patents apply

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves