401633

1-Pyrenmethylamin -hydrochlorid

95%

• Synonym(e): PMA
• Empirische Formel (Hill-System): C₁₇H₁₃N · HCl
• CAS-Nummer: 93324-65-3
• Molekulargewicht: 267.75
• MDL-Nummer: MFCD00192425
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24865033
• NACRES: NA.22
• Form: powder
• Assay: 95%

Eigenschaften

• Qualitätsniveau: 200
• Assay: 95%
• Form: powder
• mp (Schmelzpunkt): 258 °C (dec.) (lit.)
• Funktionelle Gruppe: amine
• SMILES String: Cl[H].NCc1ccc2ccc3cccc4ccc1c2c34
• InChI: 1S/C17H13N.ClH/c18-10-14-7-6-13-5-4-11-2-1-3-12-8-9-15(14)17(13)16(11)12;/h1-9H,10,18H2;1H
• InChIKey: RGNMXKKNDSHTFD-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

1-Pyrenemethylamine hydrochloride is an organic building block.

Anwendung

1-Pyrenemethylamine (PyNH₂) has also been used for the synthesis of:

• Pyrenyl hyaluronan (Py-HA), a pyrenyl-based polymer that can be used for the development of pH-triggered drug carriers.[1]
• An electrochemical electrode of reduced graphene oxide bound with pyrene functionalized folic acid derivative.[2]

It can also be used for the synthesis of 4,6-dichloro-2-pyrenemethylamine-1,3,5-triazine, a precursor to synthesize a star shaped polymer 4,6-bis(9H-carbazol-2-yloxy)-2-(pyrenemethylamine)-1,3,5 triazine (TPC).[3]

1-Pyrenemethylamine hydrochloride (PyNH₂) has been used for the loading of human telomerase reverse transcriptase (hTERT) small interfering RNA (siRNA) to the functionalized graphene oxide (GO) for the tumor targeting delivery of siRNA.[4]

1-Pyrenemethylamine hydrochloride has been used in the preparation of 1-pyrenemethylamine.[5] It may be used for the noncovalent functionalization of SWNTs with cationic moieties which binds strongly to the negatively charged phosphate backbone of the DNA.[6] It may be used in the preparation of the following Schiff-base ligand:

• pyren-1-ylmethyl-[2-(6-{2-[(pyren-1-ylmethylimino)-methyl]-phenoxymethyl}-pyridin-2-ylmethoxy)-benzylidene]-amine[7]
• 2(pyren-1-ylmethyl-{2-[6-(2-{[(pyren-1-ylmethyl)-amino]-methyl}- phenoxymethyl)-pyridin-2-ylmethoxy])-benzyl}-amine[7]

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves