344648

Triethylamin -trihydrofluorid

97%

• Synonym(e): Fluorwasserstoff 37% in Triethylamin
• Lineare Formel: (C₂H₅)₃N · 3HF
• CAS-Nummer: 73602-61-6
• Molekulargewicht: 161.21
• Beilstein: 5522945
• EG-Nummer: 277-550-5
• MDL-Nummer: MFCD00043294
• UNSPSC-Code: 12352101
• PubChem Substanz-ID: 24861270
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 300
• Assay: 97%
• Brechungsindex: n20/D 1.3915 (lit.)
• bp: 70 °C/15 mmHg (lit.)
• Dichte: 0.989 g/mL at 25 °C (lit.)
• Funktionelle Gruppe: amine
• SMILES String: F[H].F[H].F[H].CCN(CC)CC
• InChI: 1S/C6H15N.3FH/c1-4-7(5-2)6-3;;;/h4-6H2,1-3H3;3*1H
• InChIKey: IKGLACJFEHSFNN-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Triethylamine trihydrofluoride (TREAT-HF) is a mild and selective reagent for the fluorination of a wide variety of compounds.[1][2]

Anwendung

Mild and selective reagent that has been used in the fluorination of a wide variety of compounds. For a review, see Aldrichimica Acta.[3]

TREAT-HF can be used in the synthesis of:

• Vicinal difluorides from epoxides.[4]
• 3-fluoroazetidines.[5]
• 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA).[6]
• Multivicinal hexafluoroalkanes.[7]
• Aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines.[8]

Sicherheitshinweise

• Piktogramme: GHS06,GHS05
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330,H314
• P-Sätze: P260 - P271 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): 190.4 °F - closed cup
• Flammpunkt (°C): 88 °C - closed cup
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter