The ability of closely related platinum group metal salts (PGMS) to cross-react with the principal sensitising agent ammonium hexachloroplatinate IV was investigated in refinery workers. Selected subjects were screened by skin prick test, specific RAST, RAST inhibition, and primate PCA
The American review of respiratory disease, 134(4), 719-725 (1986-10-01)
Three groups of adult male cynomolgus monkeys (Macaca fascicularis) were exposed to either 200 micrograms/m3 ammonium hexachloroplatinate [(NH4)2PtCl6], 200 micrograms (NH4)2PtCl6 concurrently with 1 ppm ozone (O3), or to 1 ppm O3 only. The animals were exposed by inhalation for
Identification of the allergenic potency of chemicals is a key step in the safety assessment process. Predictive assays that require no or few animals are needed. To develop an alternative in vitro mouse bone marrow-derived dendritic cell (BMDC) assay to
Clinical and experimental immunology, 58(2), 478-485 (1984-11-01)
The effect of platinum group metal salts on IgE antibody synthesis in an animal model was studied with respect to the magnitude and kinetics of the response. In outbred Hooded Lister Rats immunized with 10 micrograms ovalbumin with B. pertussis
La Medicina del lavoro, 103(2), 123-129 (2012-05-25)
Occupational exposure to platinum salts may cause the onset of skin and respiratory disorders with an IgE-mediated allergic mechanism. The diagnosis of occupational asthma due to platinum salts was, in a small number of cases, achieved also via occupational specific
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