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V108

(±)-Norverapamil hydrochloride

≥98% (HPLC)

Synonym(s):

N-Nor-(±)-verapamil hydrochloride

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5 mg
Please contact Customer Service for Availability
CZK 8,190.00
CZK 6,961.50

About This Item

Empirical Formula (Hill Notation):
C26H36N2O4 · HCl
CAS Number:
67812-42-4
Molecular Weight:
477.04
NACRES:
NA.77
PubChem Substance ID:
24900707
UNSPSC Code:
12352200
MDL number:
MFCD00078605
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

CZK 6,961.50

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 15 mg/mL, clear

SMILES string

CC(C)C(CCCNCCC1=CC=C(OC)C(OC)=C1)(C#N)C2=CC(OC)=C(OC)C=C2.Cl

InChI

1S/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H

InChI key

OEAFTRIDBHSJDC-UHFFFAOYSA-N

Biochem/physiol Actions

Norverapamil is an N-demethylated metabolite of verapamil. It has significantly less calcium channel blocking ability and exhibit therapeutic activity.[1]

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(±)-Norverapamil hydrochloride ≥98% (HPLC)

Sigma-Aldrich

V108

(±)-Norverapamil hydrochloride

R-(−)-Deprenyl hydrochloride powder, ≥98% (HPLC)

Sigma-Aldrich

M003

R-(−)-Deprenyl hydrochloride

N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0657

N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride

Lorcainide hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1025

Lorcainide hydrochloride

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder or crystals

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

desiccated

solubility

H2O: 15 mg/mL, clear

solubility

H2O: >10 mg/mL

solubility

H2O: 15 mg/mL, clear

solubility

H2O: 10 mg/mL, clear

color

white to beige

color

white

color

white to beige

color

white to beige

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000191099
0000158691
0000158691
0000155201
0000191099

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J M Dethy et al.
Journal of chromatography. B, Biomedical applications, 654(1), 121-127 (1994-03-18)
An analytical method has been developed to determine simultaneously the verapamil and norverapamil enantiomers in human plasma using capillary electrophoresis. Among the cyclodextrins tested as chiral selector, only trimethyl-beta-cyclodextrin was suitable to resolve the four enantiomers. The analysis was achieved
Shan-Shan Xie et al.
The Journal of pharmacy and pharmacology, 62(4), 440-447 (2010-07-08)
The aim was to investigate the effect of Huang-Lian-Jie-Du-Decoction (HLJDD) on the pharmacokinetic behaviour of verapamil in rats. Rats orally received 3.33 g/kg of HLJDD extract for 14 days, and pharmacokinetics of verapamil was investigated after oral and intravenous verapamil.
Joong-Hwa Chung et al.
Biopharmaceutics & drug disposition, 30(2), 90-93 (2009-02-20)
Verapamil is known to be a P-glycoprotein (P-gp) substrate and norverapamil is formed via hepatic cytochrome P450 (CYP 3A) in the rat. Epigallocatechin gallate (EGCG), a flavonoid, was reported to be an inhibitor of both P-gp and CYP3A. Hence, it
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Global Trade Item Number

SKUGTIN
V108-5MG04061832964317

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