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R-(−)-Deprenyl hydrochloride

Name: <I>R</I>-(&#8722;)-Deprenyl hydrochloride
Brand: SIGMA
Price: 3590 CZK

≥98% (HPLC), MAO-B inhibitor, powder

Synonym(s):

(R)-(−)-N,α-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride, R(−)-N-α-Dimethyl-N-2-propynyl-benzeneethanamine hydrochloride, Selegiline hydrochloride

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Pack Size	SKU	Availability	Price
250 mg		Please contact Customer Service for Availability	CZK 3,590.00
1 g		Please contact Customer Service for Availability	CZK 7,390.00

About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₇N · HCl

CAS Number:

14611-52-0

Molecular Weight:

223.74

UNSPSC Code:

12352200

PubChem Substance ID:

24278577

NACRES:

NA.77

MDL number:

MFCD00069299

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

CZK 3,590.00

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Product Name

R-(−)-Deprenyl hydrochloride, powder, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]25/D −10.8°, c = 6.48 in H₂O(lit.)

color

white

mp

141-142 °C

solubility

H₂O: >10 mg/mL

originator

Sanofi Aventis

SMILES string

Cl[H].C[C@H](Cc1ccccc1)N(C)CC#C

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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1 of 1

This Item	D3630	D7071	P8013
Sigma-Aldrich M003 R-(−)-Deprenyl hydrochloride	Sigma-Aldrich D3630 Diphenhydramine hydrochloride	Sigma-Aldrich D7071 Dapoxetine hydrochloride	Sigma-Aldrich P8013 Pargyline hydrochloride
form powder	form powder	form powder	form powder or crystals
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay 98% (TLC)
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 200
originator Sanofi Aventis	originator Johnson & Johnson	originator Eli Lilly	originator -
solubility H₂O: >10 mg/mL	solubility -	solubility DMSO: ≥20 mg/mL	solubility water: 50 mg/mL, clear, colorless to faintly yellow
color white	color -	color white	color -

Biochem/physiol Actions

Selective MAO-B inhibitor; anti-Parkinsonian agent.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302,H336

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000529503

0000477504

0000340007

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Social odor recognition: a novel behavioral model for cognitive dysfunction in Parkinson's disease.

Michael M Monaghan et al.

Neuro-degenerative diseases, 7(1-3), 153-159 (2010-03-04)

Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by an increasing loss of dopaminergic neurons resulting in motor dysfunction. However, cognitive impairments in PD patients are a common clinical feature that has gained increased attention. The purpose of the

Identification of Sarmentosin as a Key Bioactive from Blackcurrants (Ribes nigrum) for Inhibiting Platelet Monoamine Oxidase in Humans.

Dominic Lomiwes et al.

Journal of agricultural and food chemistry, 72(30), 16777-16789 (2024-07-19)

Previous clinical studies indicate that monoamine oxidase-B (MAO-B) inhibition by blackcurrants must be predominantly attributed to bioactives other than anthocyanins. In this natural products discovery study, MAO-A/B inhibitory phytochemicals were isolated from blackcurrants, and a double-blind crossover study investigated the

Inhibition of monoamine oxidase-a increases respiration in isolated mouse cortical mitochondria.

Olivia J Kalimon et al.

Experimental neurology, 363, 114356-114356 (2023-02-26)

Monoamine oxidase (MAO) is an enzyme located on the outer mitochondrial membrane that metabolizes amine substrates like serotonin, norepinephrine and dopamine. MAO inhibitors (MAOIs) are frequently utilized to treat disorders such as major depression or Parkinson's disease (PD), though their

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS.

Hojae Lee et al.

Nature neuroscience, 24(12), 1673-1685 (2021-11-17)

Amyotrophic lateral sclerosis (ALS) is a devastating disorder in which motor neurons degenerate, the causes of which remain unclear. In particular, the basis for selective vulnerability of spinal motor neurons (sMNs) and resistance of ocular motor neurons to degeneration in

Monoamine Oxidase-B Inhibitor Reduction in Pro-Inflammatory Cytokines Mediated by Inhibition of cAMP-PKA/EPAC Signaling.

Edward E Putnins et al.

Frontiers in pharmacology, 12, 741460-741460 (2021-12-07)

Mucosal epithelial cell integrity is an important component of innate immunity and it protects the host from an environment rich in microorganisms. Virulence factors from Gram-negative bacteria [e.g. lipopolysaccharide (LPS)] induce significant pro-inflammatory cytokine expression. Monoamine oxidase (MAO) inhibitors reduce

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Global Trade Item Number

SKU	GTIN
M003-250MG	04061835557653
M003-1G	04061835512720

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