T7165

Tyrphostin 23

≥98%

• Synonym(s): (3,4-Dihydroxybenzylidene)malononitrile, RG-50810
• Empirical Formula (Hill Notation): C₁₀H₆N₂O₂
• CAS Number: 118409-57-7
• Molecular Weight: 186.17
• NACRES: NA.77
• PubChem Substance ID: 24278041
• UNSPSC Code: 12352200
• MDL number: MFCD00133899
• Assay: ≥98%
• Form: powder

Properties

• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98%
• form: powder
• potency: 35 μM IC₅₀
• solubility: DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(cc1O)\C=C(\C#N)C#N
• InChI: 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
• InChI key: VTJXFTPMFYAJJU-UHFFFAOYSA-N
• Gene Information: human ... CDK2(1017)

Description

Application

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells[1]. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils[2].

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain[3],[4].

Features and Benefits

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)