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M9440

Methyl-3,4-dephostatin

>98% (HPLC), powder

Synonym(s):

3,4-Dihydroxy-N-methyl-N-nitrosoaniline

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Size/SKUAvailabilityPrice
1 mg
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CZK 5,000.00

About This Item

Empirical Formula (Hill Notation):
C7H8N2O3
CAS Number:
Molecular Weight:
168.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
>98% (HPLC)
Form:
powder

CZK 5,000.00


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Quality Segment

assay

>98% (HPLC)

form

powder

color

red-brown

solubility

DMSO: soluble 18 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

CN(N=O)c1ccc(O)c(O)c1

InChI

1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3

InChI key

XAKAQCMEMMZUEO-UHFFFAOYSA-N

Gene Information

human ... PTPN1(5770)

Application

Methyl-3,4-dephostatin has been used as:
  • an inhibitor for methyltransferases
  • a kinase-related inhibitor for human transglutaminase[1]
  • a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein

Biochem/physiol Actions

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain.[2] It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells.[3] Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).[4]
Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.

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This Item
E1904SML1887SML2883
assay

>98% (HPLC)

assay

>99% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble 18 mg/mL, H2O: insoluble

solubility

DMSO: soluble 22 mg/mL, H2O: soluble 8 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

red-brown

color

brown

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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