SML2640
YZ129
≥98% (HPLC)
Synonym(s):
4-(6-Isoquinolinylamino)-1,2-naphthalenedione, 4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione, YZ-129, YZ129
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 2 210,00 CZK 1 878,50 CZK |
25 mg | Please contact Customer Service for Availability | 7 140,00 CZK 6 069,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C19H12N2O2
CAS Number:
Molecular Weight:
300.31
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
1 878,50 CZK
List Price2 210,00 CZKSave 15%Web-Only Promotion
Please contact Customer Service for Availability
assay
≥98% (HPLC)
form
powder
color
faint brown-red to dark red
solubility
DMSO: 0.5 mg/mL, clear
storage temp.
2-8°C
SMILES string
N(c3cc4c(cncc4)cc3)C1=CC(=O)C(=O)c2c1cccc2
InChI key
NYDMVPHEEBVAHT-UHFFFAOYSA-N
Biochem/physiol Actions
Hsp90 inhibitor with anti-cancer efficacy in vitro and in vivo.
YZ129 is an ATP site-targeting Hsp90 inhibitor (IC50 = 29.5 nM against 2.5 nM geldanamycin-FITC for binding human HSP90α) that prevents thapsigargin (1 μM)-induced NFAT nuclear translocation in HeLa cells (IC50 = 820 nM) by blocking HSP90 client calcineurin-mediated NFAT dephosphorylation. YZ129 (5 μM; 24-48 hr) suppresses U87 glioblastoma (GBM) cell migration and proliferation as a result of G2/M arrest and apoptosis induction. Daily intraperitoneal administration is efficacious against U87 xenografts (s.c.; bilateral posterior limbs)-derived tumor growth in mice in vivo.
Other Notes
Product may exist in a Tautomeric Form.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 0.5 mg/mL, clear | solubility DMSO: >20 mg/mL | solubility DMSO: 10 mg/mL, clear | solubility DMSO: 25 mg/mL, clear |
| color faint brown-red to dark red | color yellow | color white to beige | color white to beige |
Storage Class
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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