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SML1268

BQU57

≥98% (HPLC)

Synonym(s):

6-Amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile, 6-Amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]-pyrano[2,3-c]pyrazole-5-carbonitrile

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Size/SKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
9 790,00 CZK

About This Item

Empirical Formula (Hill Notation):
C16H13F3N4O
CAS Number:
Molecular Weight:
334.30
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

9 790,00 CZK


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1ccc(cc1)C2c3c([n](nc3C)C)OC(=C2C#N)N

InChI

1S/C16H13F3N4O/c1-8-12-13(9-3-5-10(6-4-9)16(17,18)19)11(7-20)14(21)24-15(12)23(2)22-8/h3-6,13H,21H2,1-2H3

InChI key

IJCMHHSFXFMZAI-UHFFFAOYSA-N

Biochem/physiol Actions

BQU57 is a selective inhibitor of the Ras-like GTPases RalA and RalB, downstream mediators of Ras signalling, without direct inihibition of Ras or RhoA activity . BQU57 binds to a site on the GDP-bound form of Ral, its inactive state, inhibiting the binding of Ral to its effectors, such as Ral-binding protein 1 (RALBP1; also known as RLIP760, which are involved in proliferation, survival, and metastasis of several human cancers. BQU57 inhibited growth in human luung cancer cell lines with IC50 values of 2.0 μM in H2122 cells and 1.3 μM in H358 cells, and also inihbited tumor xenograft growth.
BQU57 is a selective inhibitor of the Ras-like GTPases RalA and RalB.

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This Item
SML020243847
description

≥98% (HPLC)

description

≥98% (HPLC)

description

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

form

powder

form

powder

form

-

Quality Level

100

Quality Level

100

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

solubility

-

color

white to beige

color

white to tan

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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