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SML1645

SBI-0640756

≥98% (HPLC)

Synonym(s):

6-Chloro-3-[3-(5-fluoro-pyridin-3-yl)-acryloyl]-4-phenyl-1H-quinolin-2-one, SBI-756

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About This Item

Empirical Formula (Hill Notation):
C23H14ClFN2O2
CAS Number:
Molecular Weight:
404.82
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

FC1=CN=CC(/C=C/C(C2=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)NC2=O)=O)=C1

InChI

1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+

InChI key

VVWGPQZBDQVQRC-RMKNXTFCSA-N

Biochem/physiol Actions

SBI-0640756 is a potent inhibitor of eIF4G1 that disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.
SBI-0640756 is a potent inhibitor of eIF4G1.

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This Item
SML2632SML0287SML0965
form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 1 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Global Trade Item Number

SKUGTIN
SML1645-25MG04061833226438
SML1645-5MG04061833226445

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