SML0287
680C91
≥98% (HPLC), Tryptophan 2,3-dioxygenase inhibitor, powder
Synonym(s):
6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl)-1H-indole
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 2 750,00 CZK 2 337,50 CZK |
25 mg | Please contact Customer Service for Availability | 11 000,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C15H11FN2
CAS Number:
Molecular Weight:
238.26
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
2 337,50 CZK
List Price2 750,00 CZKSave 15%Web-Only Promotion
Please contact Customer Service for Availability
Product Name
680C91, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1
InChI
1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+
InChI key
YBSDQTBCNYWBMX-ONEGZZNKSA-N
Application
680C91 has been used:
- as a tryptophan 2,3 dioxygenase (TDO) inhibitor to study its effects on the pigmentation in Doryteuthis pealeii embryos
- as a TDO inhibitor to study its effects on esophageal squamous cell carcinoma in xenograft tumor assay
- as a tryptophan 2,3 dioxygenase 2 (TDO2) inhibitor to study its effects on toxic fragment formation in human embryonic kidney cells
Biochem/physiol Actions
680C91 is a potent inhibitor of the enzyme tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin. Kynurenin has recently been identified as an endogenous lignd of the arylhydrocarbon receptor (AHR). TDO is highly expressed in glioma cells, and contributes to AHR-mediated glioma cell survival and suppression of anti-tumor immune responses.
680C91 is a potent inhibitor of the enzyme tryptophan 2,3-dioxygenase (TDO).
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description recombinant, expressed in E. coli | description clone 7A6.1, from mouse |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - | assay - |
| form powder | form powder | form frozen liquid | form - |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −70°C | storage temp. - |
| solubility DMSO: ≥10 mg/mL | solubility DMSO: 2 mg/mL, clear | solubility - | solubility - |
| color white to beige | color white to beige | color - | color - |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Dam. 1
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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