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I135

Imetit dihydrobromide

≥98% (HPLC)

Synonym(s):

S-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide

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10 mg
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CZK 4,050.00
CZK 3,442.50

About This Item

Empirical Formula (Hill Notation):
C6H10N4S · 2HBr
CAS Number:
32385-58-3
Molecular Weight:
332.06
NACRES:
NA.77
PubChem Substance ID:
24277783
UNSPSC Code:
12352200
MDL number:
MFCD00153816
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

CZK 3,442.50

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 20 mg/mL, clear

SMILES string

Br[H].Br[H].NC(=N)SCCc1c[nH]cn1

InChI

1S/C6H10N4S.2BrH/c7-6(8)11-2-1-5-3-9-4-10-5;;/h3-4H,1-2H2,(H3,7,8)(H,9,10);2*1H

InChI key

DOBOYMKCRRLTRF-UHFFFAOYSA-N

Gene Information

human ... HRH3(11255)

Biochem/physiol Actions

Potent and selective H3 histamine receptor agonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
A5879I4034D204
Imetit dihydrobromide ≥98% (HPLC)

Sigma-Aldrich

I135

Imetit dihydrobromide

2-(2-Aminoethyl)isothiourea dihydrobromide

Sigma-Aldrich

A5879

2-(2-Aminoethyl)isothiourea dihydrobromide

Immepip dihydrobromide ≥97% (HPLC), powder

Sigma-Aldrich

I4034

Immepip dihydrobromide

S-(+)-O-Desmethylraclopride hydrobromide solid, ≥98% (HPLC)

Sigma-Aldrich

D204

S-(+)-O-Desmethylraclopride hydrobromide

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: 20 mg/mL, clear

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to yellow

solubility

H2O: 10 mg/mL, clear

solubility

H2O: 10 mg/mL

color

white to beige

color

-

color

white to beige

color

white

Gene Information

human ... HRH3(11255)

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Gene Information

-

Gene Information

-

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000077588
0000077589
0000040632
0000039692
104M4744V

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M Garbarg et al.
The Journal of pharmacology and experimental therapeutics, 263(1), 304-310 (1992-10-01)
The effects of a new agonist of histamine (HA) H3 receptors, Imetit (S-[2-(4-(imidazolyl)ethyl]isothiourea) were investigated in vitro and in vivo and compared to those of (R)-alpha-methylhistamine [(R)-alpha-MeHA], a prototypic drug. Imetit inhibited the binding of [3H](R-alpha-MeHA to rat brain membranes
Balasubramaniam Annamalai et al.
ACS chemical neuroscience, 11(3), 466-476 (2020-01-10)
Reuptake and clearance of released serotonin (5-HT) are critical in serotonergic neurotransmission. Serotonin transporter (SERT) is mainly responsible for clearing the extracellular 5-HT. Controlled trafficking, phosphorylation, and protein stability have been attributed to robust SERT activity. H3 histamine receptors (H3Rs)
Nayeli Rivera-Ramírez et al.
Neurochemistry international, 101, 38-47 (2016-11-05)
The histamine H3 receptor (H3R) is abundantly expressed in the Central Nervous System where it regulates several functions pre and postsynaptically. H3Rs couple to Gαi/o proteins and trigger or modulate several intracellular signaling pathways, including the cAMP/PKA pathway and the
View All Related Papers

Global Trade Item Number

SKUGTIN
I135-10MG04061832091389
I135-25MG04061832091396

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