Key Documents

View All Documentation

2-(2-Aminoethyl)isothiourea dihydrobromide

Name: 2-(2-Aminoethyl)isothiourea dihydrobromide
Brand: SIGMA
Price: 2460 CZK

≥98% (TLC), NOS inhibitor, powder

Synonym(s):

2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide, AET, S-(2-Aminoethyl)isothiouronium bromide hydrobromide

Select a Size

Change View

Pack Size	SKU	Availability	Price
25 g		Please contact Customer Service for Availability	CZK 2,460.00
100 g		Please contact Customer Service for Availability	CZK 7,710.00

About This Item

Linear Formula:

NH₂CH₂CH₂SC(=NH)NH₂ · 2HBr

CAS Number:

56-10-0

Molecular Weight:

281.01

NACRES:

NA.77

PubChem Substance ID:

24278229

UNSPSC Code:

12352200

EC Number:

200-257-0

MDL number:

MFCD00037011

Beilstein/REAXYS Number:

3911163

Assay:

≥98% (TLC)

Form:

powder

Quality level:

100

CZK 2,460.00

Please contact Customer Service for Availability

Request a Bulk Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

2-(2-Aminoethyl)isothiourea dihydrobromide,

assay

≥98% (TLC)

Quality Level

100

form

powder

mp

190-196 °C (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to yellow

SMILES string

Br[H].Br[H].NCCSC(N)=N

InChI

1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H

InChI key

XDVMCVGTDUKDHL-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).

Biochem/physiol Actions

Inhibits constitutive and inducible NOS.

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000511219

0000482458

0000429609

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Repeated cardiac pacing extends the time during which canine hearts are protected against ischaemia-induced arrhythmias: role of nitric oxide.

A Kis et al.

Journal of molecular and cellular cardiology, 31(6), 1229-1241 (1999-06-18)

Right ventricular pacing in lightly anaesthetized dogs (4x5 min periods at a pacing rate of 220 beats/min) protects against the consequences of coronary artery occlusion when this is initiated 24 h after the pacing stimulus. The main purpose of the

Adjuvant Endocrine Therapy in Patients with Ductal Carcinoma In Situ: A Population-Based Retrospective Analysis from 2005 to 2012 in the National Cancer Data Base.

Meghan R Flanagan et al.

Annals of surgical oncology, 22(10), 3264-3272 (2015-07-24)

Adjuvant endocrine therapy (AET) has been shown to reduce the risk of second breast cancer events in women with ductal carcinoma in situ (DCIS). There is no population-level evaluation of AET use in DCIS patients after standardized reporting of estrogen

Use of selective and nonselective nitric oxide synthase inhibitors in rat endotoxemia: effects on hepatic morphology and function.

Y Gundersen et al.

Shock (Augusta, Ga.), 8(5), 368-372 (1997-11-15)

Endotoxin has profound effects on nitric oxide (NO) production, and considerable controversies exist as to whether these alterations are beneficial or deleterious. Increased mortality has been reported from nonselective inhibition of NO synthase. Results from selective inhibition of the inducible

Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia.

Y Wang et al.

Shock (Augusta, Ga.), 10(1), 20-25 (1998-08-04)

The vasodilator nitric oxide (NO) is involved in the regulation of systemic blood pressure and local organ blood flow. Inhibitors of the constitutively expressed nitric oxide synthase in endothelial cells (eNOS), e.g., Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME), aggravated liver injury

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity.

G J Southan et al.

British journal of pharmacology, 114(2), 510-516 (1995-01-01)

1. The induction of a calcium-independent isoform of nitric oxide (NO) synthase (iNOS) and a subsequent enhanced formation of NO has been implicated in the pathophysiology of a variety of diseases including inflammation and circulatory shock. Here we demonstrate that

View All Related Papers

Global Trade Item Number

SKU	GTIN
A5879-100G	04061833376553
A5879-25G	04061833376560

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service