H3040

HER2 (676-end), active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(s): ERBB2, NEU, NGL, TKR1, c-erb B2
• NACRES: NA.32
• UNSPSC Code: 51111800
• Form: buffered aqueous glycerol solution
• Assay: ≥70% (SDS-PAGE)
• Recombinant: expressed in baculovirus infected Sf9 cells
• Mol wt: ~116 kDa

Properties

• recombinant: expressed in baculovirus infected Sf9 cells
• product line: PRECISIO^® Kinase
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 9-13 nmol/min·mg
• mol wt: ~116 kDa
• UniProt accession no.: P04626
• relevant disease(s): cancer (breast)
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... ERBB2(2064)

Description

General description

HER2 (eceptor tyrosine-protein kinase erbB-2) is a cell surface-associated glycoprotein tyrosine kinase receptor.[1][2]

Biochem/physiol Actions

HER2 (receptor tyrosine-protein kinase erbB-2) is an oncogene and is up-regulated in breast cancer. Overexpression of HER2 is associated with uncontrolled cellular proliferation, resistance to apoptotic cell death and increased motility.[1][2]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)