F7930

FGFR3 (397-end), active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(s): Eph receptor tyrosine kinase, growth hormone receptor, ACH, CD333, CEK2, HSFGFR3EX, JTK4
• NACRES: NA.32
• UNSPSC Code: 51111800
• Form: buffered aqueous glycerol solution
• Assay: ≥70% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in baculovirus infected Sf9 cells
• Mol wt: ~73 kDa

Properties

• biological source: human
• Quality Level: 200
• recombinant: expressed in baculovirus infected Sf9 cells
• product line: PRECISIO^® Kinase
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 95-129 nmol/min·mg
• mol wt: ~73 kDa
• packaging: pkg of 10 μg
• technique(s): cell based assay: suitable
• solubility: water: soluble
• Protein ID accession no.: NM 000142
• UniProt accession no.: P22607
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FGFR3(2261)

Description

General description

Research area: Cancer


FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.[1]FGFR3 has a strong affinity for canonical FGF ligands.

Biochem/physiol Actions

FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. [2] This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma [2] and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.[3]Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. [2] FGFR3 also plays hepatoprotective function during liver damage. [4]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)