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G002

Isoguvacine hydrochloride

solid

Synonym(s):

1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride

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25 mg
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CZK 2,240.00
100 mg
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CZK 4,860.00

About This Item

Empirical Formula (Hill Notation):
C6H9NO2 · HCl
CAS Number:
68547-97-7
Molecular Weight:
163.60
NACRES:
NA.77
PubChem Substance ID:
24278160
UNSPSC Code:
12352200
MDL number:
MFCD00055192
Form:
solid
Quality level:
200

CZK 2,240.00

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form

solid

Quality Level

200

color

white

solubility

H2O: soluble (refrigerate if not used immediately.), methanol: slightly soluble, neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)

SMILES string

Cl[H].OC(=O)C1=CCNCC1

InChI

1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H

InChI key

SUWREQRNTXCCBL-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Application

Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABAA) receptor agonist:
  • to study its effects on neuronal activity in rats[1]
  • to study its antiallodynic effect in rats[2]
  • to study its effects on baroreflex gains in rats

Biochem/physiol Actions

Isoguvacine is a strong γ-aminobutyric acid A (GABAA) receptor agonist.[3]

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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1 of 1

This Item
N7510Q0632N142
Isoguvacine hydrochloride solid

Sigma-Aldrich

G002

Isoguvacine hydrochloride

Nicardipine hydrochloride powder, ≥98%

Sigma-Aldrich

N7510

Nicardipine hydrochloride

Quinapril hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

Q0632

Quinapril hydrochloride

NO-711 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

N142

NO-711 hydrochloride

form

solid

form

powder

form

solid

form

powder

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: soluble (refrigerate if not used immediately.), neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily), methanol: slightly soluble

solubility

DMSO: ~1 mg/mL, 0.1 M NaOH: insoluble, H2O: slightly soluble, methanol: soluble

solubility

H2O: >10 mg/mL

solubility

H2O: 10 mg/mL at 60 °C

color

white

color

yellow

color

white

color

-

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

Gene Information

human ... ACE(1636)

Gene Information

human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000506518
0000506518
0000477102
0000477102
0000445586

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds.
P Krogsgaard-Larsen et al.
Journal of neurochemistry, 30(6), 1377-1382 (1978-06-01)
Frederik Rode et al.
European journal of pharmacology, 516(2), 131-138 (2005-06-07)
Gamma aminobutyric acid (GABA) plays a major role in the central hyperexcitabilty associated with nerve damage. The precise antinociceptive actions mediated by GABA(A) receptor agonists remain unclear as previous studies have shown mixed results in neuropathic pain models. Thus, various
J W Polson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 293(5), R1954-R1960 (2007-09-07)
Microinjection of angiotensin II into the nucleus tractus solitarii attenuates the baroreceptor reflex-mediated bradycardia by inhibiting both vagal and cardiac sympathetic components. However, it is not known whether the baroreflex modulation of other sympathetic outputs (i.e., noncardiac) also are inhibited
View All Related Papers

Global Trade Item Number

SKUGTIN
G002-100MG04061832090887
G002-25MG04061833623169

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