C0483

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin

≥95%, solid

• Synonym(s): Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC
• Empirical Formula (Hill Notation): C₃₅H₄₄N₄O₉
• Molecular Weight: 664.75
• NACRES: NA.77
• PubChem Substance ID: 329774798
• UNSPSC Code: 12352209
• MDL number: MFCD01074989
• Assay: ≥95%
• Form: solid

Properties

• Quality Segment: 200
• assay: ≥95%
• form: solid
• solubility: DMSO: soluble
• storage temp.: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
• InChI: 1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1
• InChI key: FOYHOBVZPWIGJM-KCHLEUMXSA-N

Description

General description

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide.[1] It acts as a substrate for caspase-like activity.[2]

Application

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle,[3] neonatal cardiomyocytes[4] and rat brain samples.[5]

Biochem/physiol Actions

Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.

Fluorogenic substrate to measure peptidylglutamyl-peptide hydrolyzing activity of 20S proteasome.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)