264103

Sodium deoxycholate

ULTROL^® Grade, ≥99% (TLC), detergent to solubilize membrane-bound proteins in their native state

• Synonym(s): Sodium deoxycholate, 3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt
• Empirical Formula (Hill Notation): C₂₄H₃₉NaO₄
• CAS Number: 302-95-4
• Molecular Weight: 414.55
• NACRES: NA.21
• UNSPSC Code: 12161902
• Beilstein/REAXYS Number: 3581950
• MDL number: MFCD00064139

Properties

• description: Merck USA index - 14, 2899
• Quality Segment: 100
• assay: ≥99% (TLC)
• form: solid
• mol wt: micellar avg mol wt 1200-5000, micellar wt 1200-4900
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• aggregation number: 3 - 12, 3-12
• color: white
• pKa: 6.2
• CMC: 2 - 6 mM, 2-6 mM (20-25°C)
• HLB: 16
• shipped in: ambient
• storage temp.: 15-25°C
• SMILES string: [Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
• InChI key: FHHPUSMSKHSNKW-SMOYURAASA-M

Description

General description

Absorbance (10%, H₂O, 290 nm):≤0.25.

Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state (absorbance: <0.25 at 290 nm, 10% H₂O; aggregation number: 3-12; CMC: 2-6 mM; micellar weight: 1200-4900; pK_a: 6.2). Reported to induce tyrosine phosphorylation of β-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 µM).

Application

• Treatment of mucocutaneous leishmaniasis - A systematic review.: Sodium deoxycholate is discussed in this systematic review as a component in treatment regimens for mucocutaneous leishmaniasis, offering comprehensive insights into current therapeutic approaches and outcomes (Fischer et al., 2024).

Preparation Note

Do not use with Mn²⁺ in solution.

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C. Discard if bacterial or fungal growth is observed.

Other Notes

Pai, R., et al. Mol. Biol. Cell15, 2156.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable