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208293

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01

The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.

Synonym(s):

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, TMEM16 Blocker I, ANO Blocker I, Anoctamin Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I

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Pack SizeSKUAvailabilityPrice
10 mg

Estimated to ship onMay 07, 2026fromAreál Kühne+Nagel spol. s r.o.

CZK 4,580.00

About This Item

Empirical Formula (Hill Notation):
C18H21NO4S
CAS Number:
407587-33-1
Molecular Weight:
347.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD02919058
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

CZK 4,580.00

Estimated to ship onMay 07, 2026Details

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Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL, pale yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1

InChI key

ACLUEOBQFRYTQS-UHFFFAOYSA-N

General description

An aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).

Packaging

Packaged under inert gas

Other Notes

Fuente, R., et al. 2011, Mol Pharmacol.73, 758.
Namkung, W., et al. 2011, J Biol Chem.286, 2365.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
613551484100613550
Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.

Sigma-Aldrich

208293

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01

TMEM16A Inhibitor, T16Ainh-A01 The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.

Sigma-Aldrich

613551

TMEM16A Inhibitor, T16Ainh-A01

5-Nitro-2-(3-phenylpropylamino)benzoic Acid Potent Cl⁻ channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method.

Sigma-Aldrich

484100

5-Nitro-2-(3-phenylpropylamino)benzoic Acid

TMEM16A Activator, Eact The TMEM16A Activator, Eact modulates the biological activity of TMEM16A. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sigma-Aldrich

613550

TMEM16A Activator, Eact

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

solid

form

powder

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

10-30°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiao-Long Li et al.
British journal of pharmacology, 179(12), 3043-3060 (2021-12-29)
Renal fibrosis is the final common outcome in most forms of chronic kidney disease (CKD). However, the underlying causal mechanisms remain obscure. The present study examined whether transmembrane member 16A (TMEM16A), a Ca2+ -activated chloride channel, contributes to the progression
F Christopher Peritore-Galve et al.
Gut microbes, 15(1), 2225841-2225841 (2023-06-23)
Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determinants of disease. However, the pathophysiological causes of diarrhea during CDI are not

Global Trade Item Number

SKUGTIN
208293-10MG04055977203264

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