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484100

5-Nitro-2-(3-phenylpropylamino)benzoic Acid

Potent Cl⁻ channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method.

Synonym(s):

5-Nitro-2-(3-phenylpropylamino)benzoic Acid, NPPB, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II, ANO Blocker II, Anoctamin Blocker II

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About This Item

Empirical Formula (Hill Notation):
C16H16N2O4
CAS Number:
107254-86-4
Molecular Weight:
300.31
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD00153851
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

yellow

solubility

DMSO: 5 mg/mL, warm ethanol: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

[N+](=O)([O-])c1cc(c(cc1)NCCCc2ccccc2)C(=O)O

InChI

1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)

InChI key

WBSMIPAMAXNXFS-UHFFFAOYSA-N

General description

Potent Cl– channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 µM).
Potent Cl- channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 µM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Cl⁻ channel blocker
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM-100 µM as Cl-channel blocker

Other Notes

Illek, B., et al. 1992. Am. J. Physiol.263, C644.
Kirk, K., et al. 1992. J. Biol. Chem.267, 23475.
Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun.163, 398.
Wangermann, P., et al. 1986. Pflugers Arch.407, S128.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
444225528108481981
5-Nitro-2-(3-phenylpropylamino)benzoic Acid Potent Cl⁻ channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method.

Sigma-Aldrich

484100

5-Nitro-2-(3-phenylpropylamino)benzoic Acid

MMP-3 Inhibitor II The MMP-3 Inhibitor II, also referenced under CAS 161314-17-6, controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444225

MMP-3 Inhibitor II

PI 3-Kγ Inhibitor II The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

528108

PI 3-Kγ Inhibitor II

Nifedipine Relatively selective blocker of L-type Ca2+ channels.

Sigma-Aldrich

481981

Nifedipine

form

solid

form

solid

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (UV)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

10-30°C

storage temp.

10-30°C

storage temp.

2-8°C

storage temp.

10-30°C

storage condition

OK to freeze

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
484100-10MG04055977200676

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