Key Documents

Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody

Name: Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody
Brand: MM
Price: 10900 CZK
Availability: InStock

Upstate^®, from rabbit

Synonym(s):

c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)

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Pack Size	SKU	Availability	Price
100 μL		Estimated to ship onMay 13, 2026fromAreál Kühne+Nagel spol. s r.o.	CZK 10,900.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Clone:

polyclonal

Species reactivity:

mouse, human

Application:

ICC, IF, WB

Citations:

CZK 10,900.00

Estimated to ship onMay 13, 2026Details

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Properties

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

species reactivity (predicted by homology)

rat (based on 100% sequence homology)

manufacturer/tradename

Upstate^®

technique(s)

immunocytochemistry: suitable, immunofluorescence: suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_000245.2

UniProt accession no.

P08581

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr1230/pTyr1234/pTyr1235)

Gene Information

human ... MET(4233)
mouse ... Met(17295)
rat ... Met(24553)

Description

General description

155 kDa

Immunogen

Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-c-Met (Tyr1230/Tyr1234/Tyr1235)

Application

Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody is an antibody against phospho-Met (Tyr1230/Tyr1234/Tyr1235) for use in IC, IF & WB.

Immunoblot Analysis: A 1:1000 dilution of this lot detected phospho-Met (Tyr1230/Tyr1234/Tyr1235) in RIPA lysate of HGF treated 293T cells.

Biochem/physiol Actions

Recognizes Met phosphorylated on both Tyr1234/Tyr1235 and Tyr1230/Tyr1234/Tyr1235.

Analysis Note

Routinely evaluated by immunoblot.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Show Differences

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This Item	07-807	07-758	05-1049
Sigma-Aldrich 07-810 Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody	Sigma-Aldrich 07-807 Anti-phospho-Met (Tyr1003) Antibody	Sigma-Aldrich 07-758 Anti-phospho-Flt-1 (Tyr1213) Antibody	Sigma-Aldrich 05-1049 Anti-Met (extracellular) Antibody, clone 4F8.2
clone polyclonal	clone polyclonal	clone polyclonal	clone 4F8.2, monoclonal
antibody form affinity purified immunoglobulin	antibody form affinity purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
species reactivity mouse, human	species reactivity human	species reactivity bovine, human, goat, sheep, rat, mouse	species reactivity human
Gene Information human ... MET(4233) mouse ... Met(17295) rat ... Met(24553)	Gene Information human ... MET(4233)	Gene Information bovine ... Flt1(503620) human ... FLT1(2321) mouse ... Flt1(14254) rat ... Flt1(54251)	Gene Information human ... MET(4233)
shipped in dry ice	shipped in dry ice	shipped in wet ice	shipped in wet ice

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

P Longati et al.

Oncogene, 9(1), 49-57 (1994-01-01)

The tyrosine kinase encoded by the MET proto-oncogene (p190MET) is the receptor for Hepatocyte Growth Factor/Scatter Factor (HGF/SF). Previous work has shown that autophosphorylation of p190MET enhances its enzymatic activity and that the major phosphorylation site is Tyr1235, located in

Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity.

Federica Chiara et al.

The Journal of biological chemistry, 278(31), 29352-29358 (2003-05-15)

The met oncogene, encoding the high affinity hepatocyte growth factor receptor, is the only known gene inherited in human cancer that is invariably associated with somatic duplication of the mutant locus. Intriguingly, mutated Met requires ligand stimulation in order to

Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.

Kwang-Hoon Song et al.

Hepatology (Baltimore, Md.), 46(6), 1993-2002 (2007-10-10)

Bile acid synthesis in the liver is regulated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1). Transcription of the CYP7A1 gene is inhibited by bile acids and cytokines. The rate of bile acid synthesis is reduced immediately after partial hepatectomy and

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Global Trade Item Number

SKU	GTIN
07-810	04053252740510

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