- Iodocyclization, followed by palladium-catalyzed coupling: a versatile strategy for heterocyclic library construction.
Iodocyclization, followed by palladium-catalyzed coupling: a versatile strategy for heterocyclic library construction.
Combinatorial chemistry & high throughput screening (2012-01-26)
Anton V Dubrovskiy, Nataliya A Markina, Richard C Larock
PMID22272662
ANOTACE
The iodocyclization of functionally-substituted alkynes provides an excellent way to prepare a wide range of iodoheterocycles, which can then be readily elaborated through palladium-catalyzed Suzuki-Miyaura, Sonogashira, Heck, Hartwig-Buchwald, and carbonylation processes into libraries of medicinally relevant heterocycles. The synthesis of libraries of indoles, benzofurans, benzothiophenes, isocoumarins and pyrones, cyclic imidates, isoxazoles, furans using this approach is reviewed. This technology is very versatile, proceeds under mild reaction conditions in high yields, and tolerates considerable functionality.
MATERIÁLY
Číslo produktu
Značka
Popis produktu
Sigma-Aldrich
Palladium, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis
Palladium, foil, not light tested, 25x25mm, thickness 0.00075mm, permanent polyester support, 99.75%
Palladium, foil, not light tested, 100x100mm, thickness 0.025mm, as rolled, 99.99+%
Palladium, foil, 8mm disks, thickness 0.25mm, as rolled, 99.99+%
Palladium, foil, light tested, 100x100mm, thickness 0.025mm, as rolled, 99.95%
Palladium, foil, 8mm disks, thickness 0.50mm, as rolled, 99.95%
Palladium, foil, light tested, 100x100mm, thickness 0.025mm, as rolled, 99.99+%
Palladium, foil, light tested, 100x100mm, thickness 0.047mm, as rolled, 99.95%
Palladium, foil, light tested, 100x100mm, thickness 0.075mm, as rolled, 99.95%
Palladium, foil, 8mm disks, thickness 0.25mm, as rolled, 99.95%
Palladium, wire reel, 0.5m, diameter 0.02mm, as drawn, 99.95%
Palladium, wire reel, 2m, diameter 0.25mm, as drawn, 99.99+%
Palladium, wire reel, 10m, diameter 0.25mm, hard, 99.95%
Palladium, rod, 100mm, diameter 2.0mm, 99.95%
Palladium, rod, 10mm, diameter 6.0mm, 99.95%
Palladium, foil, not light tested, 50x50mm, thickness 0.008mm, 99.95%
Palladium, wire reel, 1m, diameter 0.25mm, hard, 99.95%
Palladium, microfoil, disks, 25mm, thinness 0.05μm, specific density 63.6μg/cm2, permanent mylar 3.5μm support, 99.99%