- Application of ynamides in the synthesis of 2-amidoindoles.
Application of ynamides in the synthesis of 2-amidoindoles.
Organic letters (2008-11-28)
Karin Dooleweerdt, Thomas Ruhland, Troels Skrydstrup
PMID19035838
ANOTACE
A Pd-catalyzed, one-pot, two-step synthesis of 2-amidoindoles from ynamides and o-iodoanilines is reported. A key highlight of this sequence is that after the Sonogashira reaction, intramolecular cyclization to the indole occurs spontaneously without activation of the alkyne.
MATERIÁLY