1356971

Letrozole

United States Pharmacopeia (USP) Reference Standard

• Synonyma: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
• Empirický vzorec (Hillův zápis): C₁₇H₁₁N₅
• Číslo CAS: 112809-51-5
• Molekulová hmotnost: 285.30
• NACRES: NA.24
• PubChem Substance ID: 329750236
• UNSPSC Code: 41116107
• MDL number: MFCD00866241

Vlastnosti

• InChI: 1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
• SMILES string: N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
• InChI key: HPJKCIUCZWXJDR-UHFFFAOYSA-N
• grade: pharmaceutical primary standard
• API family: letrozole
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• Gene Information: human ... CYP19A1(1588)

Popis

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Letrozole USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Letrozole Tablets

Biochem/physiol Actions

Letrozole is a non-steroidal aromatase inhibitor.

Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Bezpečnostní informace

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2 - STOT RE 2
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable