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SRP6473

Sigma-Aldrich

NTRK2/TRKB human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonyma:

GP145-TrkB

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen


About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

tag

6-His tagged (C-terminus)

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

calculated mol wt 45 kDa
observed mol wt 60-90 kDa (DTT-reduced. Cys 32 is the predicted N-terminal.)

packaging

pkg of 10 and 50 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NTRK2(4915)

General description

The NTRK2 (neurotrophic tyrosine kinase receptor type 2) gene is mapped to human chromosome 9q21.33 and is predominantly expressed in subcutaneous fat and also expressed in visceral fat. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is “ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate”.

Biochem/physiol Actions

Neurotrophic tyrosine kinase receptor type 2 (NTRK2) is an oncogenic receptor tyrosine kinase. Abnormal expression of the NTRK2 gene is associated with several cancers including colorectal, breast and papillary thyroid cancer, lung adenocarcinoma and oral squamous cell carcinoma. NTRK2 also known as tropomyosin-related kinase B (TRKB) and is activated by binding of a number of neurotrophins including brain-derived neurotrophic factor(BDNF), neurotrophin 3 (NT-3) and neurotrophic ⅘ (NT-4/5). NTRK2 is involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.

Physical form

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Navštívit knihovnu dokumentů

A new aspect of the TrkB signaling pathway in neural plasticity.
Ohira K and Hayashi M
Current Neuropharmacology, 7(4), 276-285 (2009)
Transplantation of adipose tissue and stem cells: role in metabolism and disease.
Tran T T and Kahn C R
Nature reviews. Endocrinology, 6(4), 195-195 (2010)
Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF ?/? mouse model of amyotrophic lateral sclerosis.
Brockington A, et al.
BMC Genomics, 11(1), 203-203 (2010)
The receptor tyrosine kinase ROR1?an oncofetal antigen for targeted cancer therapy.
Hojjat-Farsangi M, et al.
Seminars in Cancer Biology, 29, 21-31 (2014)

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