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SML3331

Sigma-Aldrich

Triheptanoin

≥95% (HPLC)

Synonyma:

Dermofeel TC 7, Glycerol trienanthate, Glyceryl triheptanoate, Heptanoic acid, 1,1′,1′′-(1,2,3-propanetriyl) ester, Heptanoic acid, 1,2,3-propanetriyl ester (9CI), Heptanoin, tri- (6CI,7CI,8CI), Lanol 37T, Trienanthoin, Triheptanoic glyceride, Trioenanthoin, UX007

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
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About This Item

Empirický vzorec (Hillův zápis):
C24H44O6
Číslo CAS:
620-67-7
Molekulová hmotnost:
428.60
MDL number:
MFCD00042910
UNSPSC Code:
23201100
NACRES:
NA.77

Quality Level

100

assay

≥95% (HPLC)

form

oil

color

colorless to brown

storage temp.

−20°C

SMILES string

O(C(COC(=O)CCCCCC)COC(=O)CCCCCC)C(=O)CCCCCC

InChI

1S/C24H44O6/c1-4-7-10-13-16-22(25)28-19-21(30-24(27)18-15-12-9-6-3)20-29-23(26)17-14-11-8-5-2/h21H,4-20H2,1-3H3

InChI key

PJHKBYALYHRYSK-UHFFFAOYSA-N

Biochem/physiol Actions

Orally available triglyceride that provides 3 molar eq of saturated heptanoic acid in vivo to replenish reduced tricarboxylic acid (TCA; Krebs)-cycle intermediates.
Triheptanoin is a triglyceride with 3 molar eq. of saturated heptanoic acid (C7:0). The even-chain FA does not occur naturally and is able to bypass metabolic block induced by enzyme deficiency and to replenish reduced tricarboxylic acid/TCA-cycle (Krebs cycle or citric acid cycle/CAC) intermediates (anaplerosis) in vivo.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

404.6 °F - open cup

flash_point_c

207 °C - open cup

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Osvědčení o analýze (COA)

Lot/Batch Number
0000178614
0000257175
0000236261
0000240301
0000178614

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Keri J Fogle et al.
Molecular genetics and metabolism, 126(4), 439-447 (2019-01-27)
Seizures are a feature not only of the many forms of epilepsy, but also of global metabolic diseases such as mitochondrial encephalomyopathy (ME) and glycolytic enzymopathy (GE). Modern anti-epileptic drugs (AEDs) are successful in many cases, but some patients are
Sara Tucci et al.
Journal of lipid research, 58(1), 196-207 (2016-11-26)
A rather new approach in the treatment of long-chain fatty acid oxidation disorders is represented by triheptanoin, a triglyceride with three medium-odd-chain heptanoic acids (C7), due to its anaplerotic potential. We here investigate the effects of a 1-year triheptanoin-based diet
T M Schwarzkopf et al.
Neuroscience, 300, 201-209 (2015-05-20)
Triheptanoin, an oily substance, consists of glycerol bound to three molecules of heptanoic acid, a C7 odd-chain fatty acid. A triheptanoin-rich diet has anaplerotic effects because heptanoate metabolism yields succinate which delivers substrates to the Krebs cycle. While previous studies
Ingrid Sofia Vieira de Melo et al.
Nutricion hospitalaria, 32(1), 265-269 (2015-08-12)
the aim of this study was to evaluate the influence of consumption of a ketogenic diet supplemented with triheptanoin, a medium-chain anaplerotic triacylglycerol, on the liver fatty acid profile of Wistar rats. three groups of male Wistar rats (n =
Tesfaye W Tefera et al.
PloS one, 11(8), e0161816-e0161816 (2016-08-27)
There is increasing evidence that energy metabolism is disturbed in Amyotrophic Lateral Sclerosis (ALS) patients and animal models. Treatment with triheptanoin, the triglyceride of heptanoate, is a promising approach to provide alternative fuel to improve oxidative phosphorylation and aid ATP
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