SML1737

Beraprost sodium

≥98% (HPLC)

• Synonyma: 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta(b)benzofuran-5-butanoic acid sodium salt, Procyclin, TRK 100
• Empirický vzorec (Hillův zápis): C₂₄H₂₉O₅ · Na
• Číslo CAS: 88475-69-8
• Molekulová hmotnost: 420.47
• UNSPSC Code: 51111800
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [H][C@]12[C@](C[C@H](O)[C@H]2/C=C/[C@H](O)C(CC#CC)C)([H])OC3=C1C=CC=C3CCCC([O-])=O.[Na+]
• InChI: 1S/C24H30O5.Na/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28;/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28);/q;+1/p-1/b13-12+;
• InChI key: YTCZZXIRLARSET-UEIGIMKUSA-M

Popis

General description

Beraprost sodium is an orally active prostacyclin analog.

Biochem/physiol Actions

Beraprost sodium is a chemically stable analog of prostacyclin PGI2.

Beraprost sodium is a chemically stable analog of prostacyclin PGI2. As other prostanoids, beraprost is a potent vasodilator and possesses antithrombotic, antiproliferative and anti-inflammatory properties. Beraprost sodium activates prostaglandin I (IP) receptor, which is coupled with Gs proteins and activates adenylate cyclase. It has been studied for the treatment of pulmonary hypertension.

Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable