Přejít k obsahu
Merck
Všechny fotografie(1)

Key Documents

View All Documentation

SML0279

Sigma-Aldrich

LG100268

≥98% (HPLC)

Synonyma:

2-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]pyridine-5-carboxylic acid, AGN 192620, ALRT 268., CD 3127, LG268, LGD 100268, LGD 1268

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
Všechny fotografie(1)

About This Item

Empirický vzorec (Hillův zápis):
C24H29NO2
Číslo CAS:
153559-76-3
Molekulová hmotnost:
363.49
MDL number:
MFCD01758574
UNSPSC Code:
12352200
PubChem Substance ID:
329825287
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥5 mg/mL (warmed)

storage temp.

−20°C

SMILES string

Cc1cc2c(cc1C3(CC3)c4ccc(cn4)C(O)=O)C(C)(C)CCC2(C)C

InChI

1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)

Inchi Key

SLXTWXQUEZSSTJ-UHFFFAOYSA-N

Biochem/physiol Actions

LG100268 (LG268) is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC50 = 3-4 nM and has no activity at the RAR retinoic acid receptors.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

Zákazníci si také prohlíželi

Slide 1 of 4

1 of 4

Pioglitazone

Sigma-Aldrich

CDS021593

Pioglitazone

Pioglitazone hydrochloride ≥98% (HPLC)

Sigma-Aldrich

E6910

Pioglitazone hydrochloride

GW9662 >98% (HPLC)

Sigma-Aldrich

M6191

GW9662

Retinoic acid ≥98% (HPLC), powder

Sigma-Aldrich

R2625

Retinoic acid

Thi Xoan Hoang et al.
BioMed research international, 2019, 8059312-8059312 (2020-01-18)
All-trans retinoic acid (ATRA), an active form of vitamin A, exerts immunomodulatory functions. In this study, we examined the immune potentiating effect of ATRA on bacterial flagellin-induced NF-κB activation and proinflammatory cytokine production in human monocytic cell line THP-1. ATRA
Janine Gericke et al.
PloS one, 8(4), e62643-e62643 (2013-05-03)
Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases. The present study used topical application of selective agonists and antagonists
Amelia H Baker et al.
Chemical research in toxicology, 28(6), 1156-1166 (2015-05-02)
Organotins are members of the environmental obesogen class of contaminants because they activate peroxisome proliferator-activated receptor γ (PPARγ), the essential regulator of adipogenesis. Exposure to thiazolidinediones (PPARγ ligands used to treat type 2 diabetes) is associated with increased fractures. Diminished
Yihong Wan et al.
Journal of molecular endocrinology, 44(2), 135-142 (2009-10-24)
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is a key transcriptional regulator of both lipid metabolism and inflammation. The importance of PPARgamma is accentuated by the widespread use of synthetic PPARgamma agonists, thiazolidinediones (such as rosiglitazone), as drugs for
Hien Thi Vu et al.
BioMed research international, 2018, 5971080-5971080 (2018-09-19)
All-trans retinoic acid (ATRA) is an effective drug for the induction therapy of acute promyelocytic leukemia. However, the treatment is associated with adverse events such as retinoic acid syndrome (RAS) in some patients, whose histologic characteristics included organ infiltration by
Zobrazit všechny související dokumenty

Sortimentní položky

Nuclear Receptors (Non-Steroids)

We offer many products related to non-steroid nuclear receptors for your research needs.

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

Obraťte se na technický servis.