SAB5600064

Anti-Phospho-akt (ser473) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM251, purified immunoglobulin

• Synonyma: phosphorylation at Ser473
• UNSPSC Code: 12352203
• NACRES: NA.41

Vlastnosti

• recombinant: expressed in HEK 293 cells
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: RM251, monoclonal; recombinant monoclonal
• form: buffered aqueous glycerol solution
• species reactivity: human
• technique(s): immunoblotting: 1:1000-1:2000; immunohistochemistry: 1:200-1:500
• isotype: IgG
• NCBI accession no.: 207
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer473)
• Gene Information: human ... AKT1(207)

Popis

General description

AKT1 (AKT serine/threonine kinase 1) is also called as v-akt murine thymoma viral oncogene homolog 1 and PKB α (protein kinase B). It is expressed in liver,muscle and adipocytes. AKT1 gene is mapped to human chromosome 14q32. It is a member of AKT family that has an amino-terminal pleckstrin homology (PH) domain, a short α helical linker and a carboxyl-terminal kinase domain.

Specificity

This antibody reacts to Akt only when phosphorylated at Ser473. There is no cross-reactivity with Akt without phosphorylation at Ser473. This antibody may also react to bovine, mouse or rat Phospho-Akt (Ser473), as predicted by immunogen homology

Immunogen

Synthetic peptide corresponding to human Phospho-Akt (Ser473)

Biochem/physiol Actions

AKT1 (AKT serine/threonine kinase 1) controls the survival of cells and anti-apoptotic actions that attack the pathogenesis of several cancers, hence it plays a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Bezpečnostní informace

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable