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Key Documents

SAB4700731

Sigma-Aldrich

Monoclonal Anti-HLA-DR antibody produced in mouse

clone L243, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

L243, monoclonal

form

buffered aqueous solution

species reactivity

nonhuman primates, human, dog

concentration

1 mg/mL

technique(s)

FUNC: suitable
flow cytometry: suitable
immunoblotting: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2a

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... HLA-DRA(3122)

General description

Human leukocyte antigen (HLA)-DR is a member of HLA class II molecules. It is encoded by the gene mapped to human chromosome 6.(21} HLA class II molecules are highly expressed on B-Iymphocytes, but is also found at minimal levels on T-Iymphocytes, macrophages, thymus epithelial cells and selected cells of various body tissues. HLA-DR consists of a non-polymorphic α chain gene and up to three distinct highly polymorphic β chain genes.
The mouse monoclonal antibody L243 recognizes specifically HLA-DR molecules, both peptide-loaded and empty.

Immunogen

Human B lymphocytes

Application

Monoclonal Anti-HLA-DR antibody produced in mouse has been used in double immunofluorescent staining.

Biochem/physiol Actions

Human leukocyte antigen (HLA)-DR activates a T-cell receptor by presenting antigenic peptides derived from extracellular proteins thus, stimulating an immune response against the antigen.{22] Mutation in the gene increases the risk of susceptibility to inflammatory bowel disease (IBD), Crohn′s disease and ulcerative colitis. Overexpression of monocytic (HLA)-DR has been observed in schizophrenic patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

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Navštívit knihovnu dokumentů

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.
McGeer PL, et al.
Neuroscience Letters, 79(1-2), 195-200 (1987)
Expression of pannexin 1 and 2 in cortical lesions from intractable epilepsy patients with focal cortical dysplasia
Li S, et al.
Oncotarget, 8(4), 6883-6883 (2017)
HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis
Stokkers PC, et al.
Gut, 45(3), 395-401 (1999)
Monocytic HLA DR antigens in schizophrenic patients.
Krause D, et al.
Neuroscience Research, 72(1), 87-93 (2012)
Eric Alix et al.
Cell host & microbe, 28(1), 54-68 (2020-06-12)
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. Here, through a genome-wide mutant screen of human antigen-presenting cells
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