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SAB4700135

Sigma-Aldrich

Monoclonal Anti-CD28 antibody produced in mouse

low endotoxin, clone CD28.2, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CD28.2, monoclonal

form

buffered aqueous solution

species reactivity

nonhuman primates, human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CD28(940)

Související kategorie

General description

Cluster of differentiation 28 (CD28) antigen is a co-stimulatory receptor expressed in naive T-cells.[52} It contains a short cytoplasmic tail and two proline-rich motifs. CD28 is encoded by the gene mapped to human chromosome 2q33.2.

Immunogen

DC28.1.3.3 hybridoma cells

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cluster of differentiation 28 (CD28) antigen has a role in T-cell activation, proliferation, survival and function. It modulates thymic development, peripheral homeostasis and the suppressive functions of regulatory T cells. CD28 has a role in signal transduction and is involved in activating many adaptor proteins. Mutation in the gene increases the risk of susceptibility to rheumatoid arthritis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 10 EU/mg of the protein, as determined by the LAL test.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Lot/Batch Number

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Navštívit knihovnu dokumentů

Genetic variants at CD28, PRDM1, and CD2/CD58 are associated with rheumatoid arthritis risk
Raychaudhuri S
Nature Genetics, 41, 1313-1318 (2009)
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
Frohlich M
European Journal of Immunology, 46, 1644-1655 (2016)
CTLA-4 and Not CD28 Is a Susceptibility Gene for Thyroid Autoantibody Production
Tomer Y
The Journal of Clinical Endocrinology and Metabolism, 86, 1687-1693 (2001)
Yuki Akieda et al.
Journal of immunology (Baltimore, Md. : 1950), 194(9), 4162-4174 (2015-04-01)
In patients receiving allogeneic hematopoietic cell transplantation, chronic graft-versus-host disease (cGVHD) remains a frequent complication and resembles autoimmune diseases such as systemic lupus erythematosus and systemic sclerosis. Our previous work demonstrated the critical role of CD28 costimulation of donor T
Cheryl H Rozanski et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4717-4728 (2015-04-03)
In health, long-lived plasma cells (LLPC) are essential for durable protective humoral immunity, and, conversely, in disease are a major source of pathogenic Abs in autoimmunity, graft rejection, and allergy. However, the molecular basis for their longevity is largely unknown.

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

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