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Key Documents

SAB4300464

Sigma-Aldrich

Anti-APP (Ab-668) antibody produced in rabbit

affinity isolated antibody

Synonyma:

Anti-AAA antibody produced in rabbit, Anti-ABETA antibody produced in rabbit, Anti-ABPP antibody produced in rabbit, Anti-AD1 antibody produced in rabbit, Anti-amyloid beta (A4) precursor protein antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

100-140 kDa

species reactivity

human, mouse, rat

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

( A-V-T-P-E)

NCBI accession no.

NP_000475.1

UniProt accession no.

P05067

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APP(351)

General description

Amyloid β precursor protein (APP) is a type I transmembrane glycoprotein. The APP gene is mapped to human chromosome 21q21.3 and encodes various isoforms due to alternative splicing events. APP displays the ubiquitous expression, although, high levels are observed in the brain. It comprises a large ectodomain, short cytoplasmic tail, E1, and E2 domains. The E1 domain harbors a growth factor-like domain (GFLD) and a copper-binding domain (CuBD).

Immunogen

Peptide sequence around aa. 666-670 ( A-V-T-P-E ), according to the protein APP.

Application

Anti-APP (Ab-668) antibody produced in rabbit has been used in:
  • immunohistochemistry
  • immunolabeling
  • western blotting
  • immunoprecipitation

Biochem/physiol Actions

Amyloid β precursor protein (APP) serves as a precursor of amyloid β (Aβ) peptide. It participates in synaptic function, trans-cellular synaptic adhesion, and in the anterograde transport of the virus.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

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Navštívit knihovnu dokumentů

Prasanna Satpute-Krishnan et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16532-16537 (2006-10-26)
Fast anterograde transport of membrane-bound organelles delivers molecules synthesized in the neuronal cell body outward to distant synapses. Identification of the molecular "zipcodes" on organelles that mediate attachment and activation of microtubule-based motors for this directed transport is a major
Eglė Jakubauskienė et al.
Gene, 766, 145146-145146 (2020-09-18)
The removal of introns from mRNA precursors (pre-mRNAs) is an essential step in eukaryotic gene expression. The splicing machinery heavily contributes to biological complexity and especially to the ability of cells to adapt to altered cellular conditions. Hypoxia also plays
SnapShot: genetics of Alzheimer's disease.
Rita Guerreiro et al.
Cell, 155(4), 968-968 (2013-11-12)
Rui Zhang et al.
CNS neuroscience & therapeutics, 26(2), 228-239 (2019-08-01)
As a normal physiological process, sleep has recently been shown to facilitate clearance of macromolecular metabolic wastes from the brain via the glymphatic system. The aim of the present study was to investigate pathophysiological roles of astroglial aquaporin 4 (AQP4)
Jenna M Ramaker et al.
Frontiers in molecular neuroscience, 9, 130-130 (2016-12-10)
Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a
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