SAB2101106

Anti-HTR2A antibody produced in rabbit

affinity isolated antibody

• Synonyma: Anti-5-HT2A, Anti-5-hydroxytryptamine (serotonin) receptor 2A, Anti-HTR2
• UNSPSC Code: 12352203
• NACRES: NA.41

Vlastnosti

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 52 kDa
• species reactivity: human
• concentration: 0.5 mg - 1 mg/mL
• technique(s): western blot: suitable
• UniProt accession no.: P28223
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... HTR2A(3356)

Popis

General description

5-hydroxytryptamine receptor 2A (HTR2A) encodes for a G-Protein coupled serotonin receptor. HTR2A is predominantly expressed in the brain near to serotoninergic neurons. The gene HTR2A is localized on human chromosome on 13q14.2.

Immunogen

Synthetic peptide directed towards the N terminal region of human HTR2A

Biochem/physiol Actions

5-hydroxytryptamine receptor 2A (HTR2A) binds to neurotransmitters or drugs and activates the G-protein coupled signalling pathway by stimulating phospholipase C signalling cascade and the ultimate release of calcium. and modulates cognitive functions, memory, learning etc. HTR2A is the drug targeting receptor for many of the antipsychotic drugs like serotonergic psychedelics. Genetic polymorphisms as well as epigenetic factors regulate the expression of HTR2A. These variations in the regulation lead to a wide variety of psychotic disorders like schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer′s disease.

Sequence

Synthetic peptide located within the following region: DILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSEN

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Bezpečnostní informace

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable