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S9576

Sigma-Aldrich

SR8278

≥98% (HPLC)

Synonyma:

1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester

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About This Item

Empirický vzorec (Hillův zápis):
C18H19NO3S2
Číslo CAS:
1254944-66-5
Molekulová hmotnost:
361.48
MDL number:
MFCD18782736
UNSPSC Code:
12352200
PubChem Substance ID:
329824626
NACRES:
NA.77

assay

≥98% (HPLC)

form

lyophilized powder

color

white

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

SMILES string

CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3

InChI

1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3

Inchi Key

UIEBLUZPSFAFOC-UHFFFAOYSA-N

Application

SR8278 has been used as a nuclear receptor subfamily 1, group D, member 1 (NR1D1) antagonist to study its effects on starvation-induced macrophages.
SR8278 was used as rev-erb alpha antagonist to study the regulation of glucagon secretion in mouse pancreatic alpha cells1 and beta cells.2

Biochem/physiol Actions

SR8278 is a Nuclear Heme Receptor REV-ERB antagonist. REV-ERBα plays a critical role in regulation of the circadian rhythm by repressing target gene activities. Additionally, REV-ERBα has been shown to regulate metabolic processes including lipid and glucose metabolism. SR8278 blocks the ability of the synthetic agonist GSK4112 to enhance REV-ERBα-dependent repression and stimulates the expression of REV-ERBα target genes involved in gluconeogenesis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

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