S3322

Supercinnamaldehyde

≥98% (HPLC)

• Synonyma: 1,3-Dihydro-1-methyl-3-(2-oxopropylidene)-2H-Indol-2-one
• Empirický vzorec (Hillův zápis): C₁₂H₁₁NO₂
• Číslo CAS: 70351-51-8
• Molekulová hmotnost: 201.22
• MDL number: MFCD08530327
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824530
• NACRES: NA.77

Vlastnosti

• assay: ≥98% (HPLC)
• form: powder
• color: faintly red to very dark red
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN1C(=O)C(=C\C(C)=O)\c2ccccc12
• InChI: 1S/C12H11NO2/c1-8(14)7-10-9-5-3-4-6-11(9)13(2)12(10)15/h3-7H,1-2H3/b10-7+
• InChI key: CZKBLHCEDVWPRN-JXMROGBWSA-N

Popis

Application

Supercinnamaldehyde may be used in transient receptor potential ankyrin 1 (TRPA 1)-mediated cell signaling studies.

Biochem/physiol Actions

Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator; EC₅₀ = 0.8 μM; derivative of cinnamaldehyde; covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.

Caution

Air-sensitive

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves