P9178

Prochlorperazine dimaleate salt

• Empirický vzorec (Hillův zápis): C₂₀H₂₄ClN₃S · 2C₄H₄O₄
• Číslo CAS: 84-02-6
• Molekulová hmotnost: 606.09
• EC Number: 201-511-3
• MDL number: MFCD00069330
• UNSPSC Code: 41116107
• PubChem Substance ID: 57654570
• NACRES: NA.77

Vlastnosti

• form: powder
• solubility: H₂O: slightly soluble 0.3 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL; methanol: soluble
• originator: GlaxoSmithKline
• SMILES string: OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1
• InChI: 1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• InChI key: DSKIOWHQLUWFLG-SPIKMXEPSA-N
• Gene Information: human ... DRD2(1813)

Popis

Biochem/physiol Actions

Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects. Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulates sleep. Prochlorperazine is useful as a tranquilizer in the treatment of schizophrenia and nonpsychotic anxiety.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; antispasmodic

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Bezpečnostní informace

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H336,H361d,H362
• pcodes: P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Lact. - Repr. 2 - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves