N1790

Naftifine hydrochloride

• Synonyma: Naftifine HCL
• Empirický vzorec (Hillův zápis): C₂₁H₂₁N · HCl
• Číslo CAS: 65473-14-5
• Molekulová hmotnost: 323.86
• MDL number: MFCD00059047
• UNSPSC Code: 51102829
• PubChem Substance ID: 329818590
• NACRES: NA.76

Vlastnosti

• assay: ≥99%
• Quality Level: 200
• form: powder
• solubility: ethanol: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; fungi; yeast
• mode of action: cell wall synthesis | interferes; enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• InChI key: OLUNPKFOFGZHRT-YGCVIUNWSA-N

Popis

Application

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

Biochem/physiol Actions

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable