N0756

N-Nitrosodiethylamine

liquid, nitrosamine

• Synonyma: Diethylnitrosamine
• Lineární vzorec: (C₂H₅)₂NNO
• Číslo CAS: 55-18-5
• Molekulová hmotnost: 102.14
• Beilstein/REAXYS Number: 1744991
• EC Number: 200-226-1
• MDL number: MFCD00013890
• UNSPSC Code: 12352116
• PubChem Substance ID: 24897440
• NACRES: NA.77

Vlastnosti

• Název produktu: N-Nitrosodiethylamine, liquid
• form: liquid
• Quality Level: 100
• color: yellow
• bp: 177 °C (lit.)
• density: 0.95 g/mL (lit.)
• SMILES string: CCN(CC)N=O
• InChI: 1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
• InChI key: WBNQDOYYEUMPFS-UHFFFAOYSA-N

Popis

General description

N-Nitrosodiethylamine belongs to the nitrosamines category of nitrogenous disinfection byproduct. It is also generated in chlorine based water treatment plants.

Application

N-Nitrosodiethylamine has been used to induce hepatocarcinogenesis in rat and mice.

Biochem/physiol Actions

N-Nitrosodiethylamine (NDMA) is carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. However microbes like Pseudomonas metabolize NDMA into N-nitromethylamine (NTMA) and formaldehyde.

Packaging

Bulk Package

Bezpečnostní informace

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H350,H412
• pcodes: P202 - P264 - P270 - P273 - P280 - P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter