M7695

Anti-Munc-18-3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonyma: Anti-MUNC18C, Anti-PSP, Anti-Syntaxin Binding Protein 3 (STXBP3), Anti-UNC-18C
• UNSPSC Code: 12352203
• NACRES: NA.41

Vlastnosti

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~66 kDa
• species reactivity: rat, mouse, human
• technique(s): western blot: 0.75-1.5 μg/mL using mouse brain extract (S1 fraction)
• UniProt accession no.: O00186
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... STXBP3(6814) ; mouse ... Stxbp3a(20912) ; rat ... Stxbp3(114095)

Popis

General description

Mammalian uncoordinated-18-3 (Munc-18-3) (also known as Munc-18c, syntaxin-binding protein 3, STXBP3) is ubiquitously expressed.

Immunogen

synthetic peptide corresponding to amino acids 578-592 located at the C-terminus of mouse Munc-18-3, conjugated to KLH. This sequence is highly conserved (~90% identity) in human and rat Munc-18-3.

Application

Anti-Munc-18-3 antibody produced in rabbit has been used in immunohistochemistry and western blotting

Biochem/physiol Actions

Mammalian uncoordinated-18-3 (Munc-18-3) expressed in 3T3-L1 adipocytes has been shown to interact with syntaxin 2 and 4 and to inhibit the binding of syntaxin-4 to vesicle associated membrane protein 2 (VAMP2). Munc-18c has been suggested to play a role in the docking/fusion of glucose transporter type 4 (GLUT4)-containing vesicles with the cell membrane of 3T3-L1 adipocytes. Heterozygous knock-out of the Munc-18c gene in mice impairs insulin-stimulated GLUT4 translocation in skeletal muscle and increases the susceptibility for severe glucose intolerance.

Munc-18-3 has a role in glucose metabolism and is involved in controlling the translocation of glucose transporter type 4 (GLUT4) in adipocytes.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Bezpečnostní informace

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable