M4939

Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse

≥97% (HPLC)

• Synonyma: MOG Peptide 35-55 Rat, Mouse
• Číslo CAS: 163913-87-9
• UNSPSC Code: 12352209
• NACRES: NA.26
• MDL number: MFCD02265607

Vlastnosti

• Název produktu: Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse, immunodominant epitope of MOG
• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• color: white
• UniProt accession no.: Q61885, Q63345
• application(s): cell analysis
• storage temp.: −20°C
• Gene Information: mouse ... Mog(17441) ; rat ... Mog(24558)

Popis

General description

Myelin oligodendrocyte glycoprotein (MOG) is a component of the central nervous system and present on the surface of oligodendrocytes and myelin. Its extracellular domain is widely used to generate an autoimmune animal model of multiple sclerosis. In rats, it is expressed in the hippocampus.

Application

• Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.: This paper investigates the delayed therapeutic administration of erythropoietin and its derivatives in the treatment of autoimmune encephalomyelitis, using Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 to induce the disease model in mice (Savino et al., 2006).


• Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease and neuroantigen-specific interferon-gamma production in mouse EAE.: This research explores the role of serotonin reuptake in modulating immune responses and susceptibility to autoimmune diseases, using Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 to induce experimental autoimmune encephalomyelitis in mice (Hofstetter et al., 2005).


• Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.: The study demonstrates the effectiveness of trichostatin A, a histone deacetylase inhibitor, in treating experimental autoimmune encephalomyelitis. Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 was used to induce the disease model in rats and mice, providing insights into potential epigenetic therapies (Camelo et al., 2005).

Biochem/physiol Actions

Induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.

Other Notes

Lyophilized from 0.1% TFA in H2O

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)