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I3400

Sigma-Aldrich

Interferon-γ-Inducible Protein-10 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonyma:

CXCL10, IP-10

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About This Item

MDL number:
MFCD00241912
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

0.015-0.075 μg/mL ED50 (chemoattract mouse BaF3 cells transfected with hCXCR3)
0.03-0.18 μg/mL ED50 (chemoattract T-Lymphocytes)

mol wt

8.7 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

UniProt accession no.

P01579

storage temp.

−20°C

Gene Information

human ... CXCL10(3627)

General description

The gene for C-X-C motif chemokine ligand 10 (CXCL10), also known as interferon-γ-inducible protein-10 (IP-10), is mapped to human chromosome 4q21.1. IP-10 is secreted by monocytes, neutrophils, endothelial cells, keratinocytes, fibroblasts, mesenchymal cells, dendritic cells, astrocytes and hepatocytes. It is a polypeptide of 78 amino acids. Human IP-10 shows 67% amino acid homology to mouse CRG-2.

Biochem/physiol Actions

IP-10 (interferon-γ-inducible protein-10) protein is a proinflammatory chemokine which controls immune responses. It interacts with chemokine receptor 3 (CXCR3) and activates leukocytes including T cells, eosinophils, monocytes and natural killer cells. Mutations in IP-10 are associated with rheumatoid arthritis. In humans with chronic hepatitis C virus (HCV) infection or HCV/human immunodeficiency virus (HIV) co-infection, IP-10 is linked with obesity and insulin resistance.
IP-10, a chemoattractant for activated T lymphocytes, is a potent inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hCXCR3.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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