D3321
Dipeptidyl Peptidase VII human
recombinant, expressed in Sf9 cells
Synonyma:
DPP7, Quiescent cell proline dipeptidase
Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
About This Item
Číslo enzymu podle klasifikace EK:
3.4.14.-
UNSPSC Code:
12352204
NACRES:
NA.54
Doporučené produkty
recombinant
expressed in Sf9 cells
Quality Level
form
solution
specific activity
≥1,500 units/μg protein
≥1500 units/μg protein
mol wt
89.1 kDa
relevant disease(s)
diabetes; cardiovascular diseases
shipped in
dry ice
storage temp.
−70°C
Application
Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes . DPP7 is used to study the regulation of cell quiescence . Like DPP4, DPP7 may be useful in diabetes and vascular disease research .
Biochem/physiol Actions
DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 . DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.
Physical properties
Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa
Unit Definition
One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C
Physical form
Supplied as a solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 2
Osvědčení o analýze (COA)
Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.
Již tento produkt vlastníte?
Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.
Dolan Sondhi et al.
Human gene therapy methods, 23(5), 324-335 (2012-11-08)
Late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal, lysosomal storage disorder caused by mutations in the CLN2 gene, results in a deficiency of tripeptidyl-peptidase I (TPP-I) activity in neurons. Our prior studies showed that delivery of the human CLN2 cDNA
Wengen Wu et al.
Bioorganic & medicinal chemistry letters, 22(17), 5536-5540 (2012-08-03)
The boroProline-based dipeptidyl boronic acids were among the first DPP-IV inhibitors identified, and remain the most potent known. We introduced various substitutions at the 4-position of the boroProline ring regioselectively and stereoselectively, and incorporated these aminoboronic acids into a series
Helen Hwang et al.
Structure (London, England : 1993), 20(11), 1872-1880 (2012-09-18)
Human telomeres possess a single-stranded DNA (ssDNA) overhang of TTAGGG repeats, which can self-fold into a G-quadruplex structure. POT1 binds specifically to the telomeric overhang and partners with TPP1 to regulate telomere lengthening and capping, although the mechanism remains elusive.
Brian D Green et al.
Diabetes & vascular disease research, 3(3), 159-165 (2006-12-13)
Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) provide a strategy for the treatment of type 2 diabetes. DPP IV rapidly inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Inhibition of DPP IV prolongs and
Martin Kruse et al.
The Journal of general physiology, 140(2), 189-205 (2012-08-02)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) regulates activities of numerous ion channels including inwardly rectifying potassium (K(ir)) channels, KCNQ, TRP, and voltage-gated calcium channels. Several studies suggest that voltage-gated potassium (K(V)) channels might be regulated by PI(4,5)P(2). Wide expression of K(V) channels in
Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..
Obraťte se na technický servis.