A2327
Adrenomedullin 52 human
≥90% (HPLC), powder
Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
About This Item
Empirický vzorec (Hillův zápis):
C264H406N80O77S3
Číslo CAS:
Molekulová hmotnost:
6028.73
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.32
Doporučené produkty
Amino Acid Sequence
Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2
General description
Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia.
Application
Adrenomedullin 52 human has been used in tube formation assay in human umbilical vein endothelial cells (HUVECs).
Biochem/physiol Actions
Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene.
Cheung BMY, et al.
European Journal of Endocrinology, 165(4), 571-577 (2011)
A Fedorowski et al.
Journal of internal medicine, 273(4), 359-367 (2013-03-21)
The aim of the study was to investigate the resting levels of novel cardiovascular biomarkers in common types of noncardiac syncope. An observational study was conducted including 255 patients (mean age 60 years, range 15-93; 45% men) with unexplained syncopal
Yosuke Suzuki et al.
Journal of peptide science : an official publication of the European Peptide Society, 19(1), 59-63 (2012-12-12)
Adrenomedullin (ADM) is a 52-amino acid peptide with a variety of physiologic functions such as immunomodulating activity, direct bactericidal activity, maintenance of renal homeostasis, and vasodilatory activity. Midregional proADM (MR-proADM) is derived from a larger 185-amino acid precursor peptide, prepro-adrenomedulin
Transcriptional regulation of adrenomedullin by oncostatin M in human astroglioma cells: Implications for tumor invasion and migration.
Lim SY, et al.
Scientific Reports, 4(4), 6444-6444 (2014)
Ben S T Wong et al.
Biology of reproduction, 88(2), 34-34 (2012-12-18)
Extravillous cytotrophoblast (EVCT) is responsible for trophoblast invasion, which is an important process during placentation. Dysregulation of the process is associated with a wide range of pregnancy complications. Adrenomedullin (ADM) is a polypeptide expressed most abundantly in first-trimester placentas. We
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