92131

Trimethoprim

≥99.0% (HPLC)

• Synonyma: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568
• Empirický vzorec (Hillův zápis): C₁₄H₁₈N₄O₃
• Číslo CAS: 738-70-5
• Molekulová hmotnost: 290.32
• UNSPSC Code: 51285203
• NACRES: NA.85
• PubChem Substance ID: 57653467
• EC Number: 212-006-2
• Beilstein/REAXYS Number: 625127
• MDL number: MFCD00036761

Vlastnosti

• biological source: synthetic
• Quality Segment: 200
• assay: ≥99.0% (HPLC)
• form: powder
• color: white to light yellow
• mp: ≥199.0 °C
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycobacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
• InChI: 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
• InChI key: IEDVJHCEMCRBQM-UHFFFAOYSA-N
• Gene Information: human ... DHFRP1(573971), KCNH1(3756) ; rat ... Dhfr(24312)

Popis

General description

Chemical structure: pyrimidine

Application

Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae .

Biochem/physiol Actions

Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).

Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Packaging

1g,5g,25g

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.

Bezpečnostní informace

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H361d
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)